abstract：:The following paper is the manuscript of an oral presentation during the annual GPOH meeting on May 22nd, 2000 in Berlin. Following her experiences as a member of the psychosocial care team of a children's cancer unit the author discusses the emotional impact of stemcell or bone marrow transplantation in children. Psy...

journal_title：Klinische Padiatrie

authors： Griessmeier B

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Most patients with terminal renal failure show arterial hypertension. In addition to casual blood pressure measurements in the clinic, home blood pressure measurement is recommended for these patients to control arterial blood pressure. PATIENTS:The study was performed in children with hemodialysis (HD; n =...

journal_title：Klinische Padiatrie

authors： Bald M,Böhm W,Feldhoff C,Bonzel KE

更新日期：2001-01-01 00:00:00

abstract：UNLABELLED:The congenital syphilis is an infectious fetopathy which is able to affect the whole organism. In most cases symptoms are not obvious before week fourth to twelve of life. The infection of the mother is the precondition for the child's disease. The placental transfer takes place after the fifth to sixth mont...

journal_title：Klinische Padiatrie

authors： Vieker S,Siefert S,Lemke J,Püst B

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The association between Hepatitis B virus infection and membranous nephropathy has been confirmed by sources in several countries. Most commonly, the illness is seen as a nephrotic syndrome. Optimal treatment remains undefined. Antiviral therapies observed with recombinant human interferon alpha may be the b...

journal_title：Klinische Padiatrie

authors： Steiss JO,Piske-Keyser K,Gröne HJ,Gortner L

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The prognosis of children with multisystem Langerhans cell histiocytosis (LCH) has improved with the application of chemotherapy. However, treatment strategies used varied from conservative approach with treatment only during disease exacerbation to intensive chemotherapy starting immediately after diagnosis...

journal_title：Klinische Padiatrie

authors： Minkov M,Grois N,Heitger A,Pötschger U,Westermeier T,Gadner H

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Neurotrophins and their cognate receptors TrkA, TrkB and TrkC regulate proliferation, differentiation and death of neuronal progenitor cells and may be implicated in the progression of medulloblastoma and other primitive neuroectodermal brain tumors (PNET). These common childhood brain tumors are composed of...

journal_title：Klinische Padiatrie

authors： Grotzer MA,Janss AJ,Phillips PC,Trojanowski JQ

更新日期：2000-07-01 00:00:00

abstract：:The diagnosis of HFI is easily missed during childhood. It should be suspected in children presenting with hepatomegaly and an isolated increase in GGT. A carefully taken nutritional history forms the basis of the diagnosis of HFI which can be confirmed by molecular analysis with a sensitivity of > 95%. I.v. fructose ...

journal_title：Klinische Padiatrie

authors： Wössmann W,Wiemann J,Körber F,Gortner L

更新日期：2000-05-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is the most common neurocutaneous disease. The clinical manifestations are diverse. Some of the skeletal changes are most relevant to the patient. We report on 9 patients with NF1 who presented with typical pseudarthrosis. In 8 of these children the lower extremity was involved. In 2 cas...

journal_title：Klinische Padiatrie

authors： Ramelli GP,Slongo T,Weis J,Tschäppler H,Vassella F

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Burning pain of red and warm hands and/or feet are the classical symptoms of erythromelalgia. CASE REPORT:We describe the symptoms of acute idiopathic erythromelalgia and arterial hypertension in a five-year-old boy. Five days after a gastroenteritis the patient developed burning hands and feet in combinati...

journal_title：Klinische Padiatrie

authors： Zenz W,Zöhrer B,Zobel G,Schulze-Bauer C

更新日期：1999-11-01 00:00:00

abstract：:We report on a 13.2 years old boy who was treated for tall stature (expected target height of 204.8 +/- 5.4 cm) with high dose of testosterone. Therapy for height reduction was started with testosterone injections (250 mg Testoviron Depot i.m.) once a week. There occurred no side effects during 6 months of treatment. ...

journal_title：Klinische Padiatrie

authors： Weimann E,Böhles HJ

更新日期：1999-09-01 00:00:00

abstract：:A multi-center retrospective survey was conducted to evaluate the incidence and types of hemostatic complications occurring in children with acute lymphoblastic leukemia (ALL) during treatment according to the ALL-BFM-90 treatment protocol. All of the BFM-treatment centers (n = 77) were approached and a 95% response r...

journal_title：Klinische Padiatrie

authors： Sutor AH,Mall V,Thomas KB

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Owing to twenty years of multicentric interdisciplinary cooperation, the COSS group has been able to collect data on a large group of osteosarcoma patients treated by neoadjuvant therapy. This paper reviews results achieved in patients with localized extremity tumors. PATIENTS AND METHODS: INCLUSION CRITER...

journal_title：Klinische Padiatrie

authors： Bielack S,Kempf-Bielack B,Schwenzer D,Birkfellner T,Delling G,Ewerbeck V,Exner GU,Fuchs N,Göbel U,Graf N,Heise U,Helmke K,von Hochstetter AR,Jürgens H,Maas R,Münchow N,Salzer-Kuntschik M,Treuner J,Veltmann U,Werner

更新日期：1999-07-01 00:00:00

abstract：:We identified betulinic acid (BetA) as a new cytotoxic agent active against neuroectodermal tumor cells including neuroblastoma, medulloblastoma, glioblastoma and Ewing's sarcoma cells representing the most common solid tumors of childhood. BetA induced apoptosis independent of wild-type p53 protein and accumulation o...

journal_title：Klinische Padiatrie

authors： Fulda S,Jeremias I,Pietsch T,Debatin KM

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Pachyonychia congenita is considered to be a genodermatosis of autosomal inheritance. It is characterized by nail hypertrophy, shortly present after birth. Later on follicular keratosis of the extremities and hyperkeratosis of palms and soles can be found. HISTORY AND CLINICAL FINDINGS:We report a child wit...

journal_title：Klinische Padiatrie

authors： Wimmershoff MB,Stolz W,Schiffner R,Landthaler M

更新日期：1999-05-01 00:00:00

abstract：:The present clinical observation is related to a 14-year-old girl suffering from acute myeloid leukemia. The clinical course was complicated by episodes of severe enterocolitis, E. coli- septicemia, pancreatitis and pneumonia. In the course of continued cytostatic and antibiotic treatment a persistent asymptomatic Lac...

journal_title：Klinische Padiatrie

authors： Majcher-Peszynska J,Heine W,Richter I,Eggers G,Mohr C

更新日期：1999-03-01 00:00:00

abstract：:Report of accidental ingestion and aspiration of lamp oil of a boy aged 16 months. He develops in a few hours a severe pneumonitis with tachycardia. Echocardiography shows diminished contractability. After losing his symptoms, the chest x-rays on the 13th day show bilateral pneumatoceles. The course remains asymptomat...

journal_title：Klinische Padiatrie

authors： Leuchter D,Stübecke W,Oberschulte-Beckmann D

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Supraventricular reentrant tachycardias are the most common cardiac arrhythmia observed in infancy and childhood. The often benign clinical course of the disease warrants careful selection of any antiarrhythmic drug given to prevent recurrencies, in order to avoid potentially dangerous side-effects such as p...

journal_title：Klinische Padiatrie

authors： Pfammatter JP,Weber JW,Stocker FP

更新日期：1998-09-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of infancy and young childhood. The clinical presentation includes recurrent unexplained fever with hepatosplenomegaly. Cytopenia, hypofibrinogenemia and/or hypertriglyceridemia and hemophagocytosis in bone marrow, spleen and lymphnode confirm the diagnosis. H...

journal_title：Klinische Padiatrie

authors： Dürken M,Schneider EM,Blütters-Sawatzki R,Stollmann-Gibbels B,Nessler G,Bretz R,Körholz D,Probst EN,Holsten-Griffin H,Harps E,Zander AR,Janka GE

更新日期：1998-07-01 00:00:00

abstract：:Since 1980, a growing number of pediatric patients with mutism following posterior fossa surgery have been recognized. This syndrome typically affects children and in rare cases young adults who become mute one or two days after tumor operation but do not show disturbances of consciousness or language comprehension. T...

journal_title：Klinische Padiatrie

authors： Janssen G,Messing-Jünger AM,Engelbrecht V,Göbel U,Bock WJ,Lenard HG

更新日期：1998-07-01 00:00:00

abstract：:For many years the nursing profession has been considered a dead-end street without any prospects of career advancement or continued qualification. This situation has thoroughly changed. Nursing as an academic specialty has been established in 24 colleges. Furthermore, on-the-job specialty training has become availabl...

journal_title：Klinische Padiatrie

authors： Voss H

更新日期：1998-07-01 00:00:00

abstract：:More than 40 years ago, Toxocara ssp. was identified as the cause of larva migrans visceralis and ocular larva migrans, which mainly affect infants and children. Although widespread in most parts of the world, the parasitic disease is rarely diagnosed in Germany. Focusing on clinical and pathophysiological similaritie...

journal_title：Klinische Padiatrie

authors： Hohenschild S

更新日期：1998-05-01 00:00:00

abstract：:630 neonates with risk factors of perinatal hearing impairment were screened of hearing loss by means of registration of transient otoacoustic emissions before discharge from the newborn nursery. Neonates were screened additionally by means of brainstem evoked response audiometry, if they had bilateral negative emissi...

journal_title：Klinische Padiatrie

authors： Sitka U,Rehm K,Rasinski C

更新日期：1998-03-01 00:00:00

abstract：:A follow-up study was undertaken to determine the predictors of the course of recurrent wheezing episodes in children (between 0 to 8 years). In 1991, 600 children with wheezing episodes had been recorded by physicians who participated in a sentinel practice network. On each consultation with the same physicians from ...

journal_title：Klinische Padiatrie

authors： Seidler A,Schlaud M,Raum E,Schwartz FW

更新日期：1998-01-01 00:00:00

abstract：:Report on two babies, 5 and 6 months old with severe salt depletion were admitted to our hospital with fever and gastro-enteritis. One of them failed to thrive despite normal nutrition, the other one had a protracted gastro-enteritis. Both of them had a great loss of weight, a strong dehydration and were in reduced ge...

journal_title：Klinische Padiatrie

authors： Sauter R,Will M,Helwig H

更新日期：1997-11-01 00:00:00

abstract：:Corticosteroids for treatment or prevention of pulmonary disease are milestones in the management of preterm infants nowadays. Prenatal maternal administration as well as postnatal treatment of the mechanically ventilated preterm infant with bronchopulmonary dysplasia (BPD) are considered to be established concepts. H...

journal_title：Klinische Padiatrie

authors： Krause M

更新日期：1997-09-01 00:00:00

abstract：:To evaluate the impact of megatherapy on the outcome of high risk neuroblastoma, 39 patients with stage IV neuroblastoma, who underwent megatherapy, were analyzed retrospectively and compared to 49 patients, who continued chemotherapy according to the German cooperative trial NB85. The groups were comparable concernin...

journal_title：Klinische Padiatrie

authors： Hero B,Kremens B,Klingebiel T,Bender-Götze C,Burdach S,Schrappe M,Berthold F

更新日期：1997-07-01 00:00:00

abstract：:During angiogenesis new blood vessels sprout from an existing vascular bed. This is a prerequisite for tumor growth beyond a certain size and for metastasis formation. Tumors produce a number of cytokines. The development of in vivo bio-assays for angiogenesis and in vitro analysis of endothelial cells permits charact...

journal_title：Klinische Padiatrie

authors： Hotfilder M,Nowak-Göttl U,Wolff JE

更新日期：1997-07-01 00:00:00

abstract：:We report of an previously unpublished combination of partial trisomy 9 and a membranous pulmonary atresia with a large conotruncal ventricular septal defect. The dystrophic female, term newborn presented after delivery with microcephaly, prominent nose and several other facial and skeletal deformities. The echocardio...

journal_title：Klinische Padiatrie

authors： Nekarda T,Kececioglu D,Kehl HG,Gehrmann J,Miny P,Vogt J

更新日期：1997-05-01 00:00:00

abstract：:In case of painful scoliosis, a search for etiologic factors in the vertebral spinal canal and adjacent structures should be made. MRI with Gadolinium is useful to look for various pathology in and around the spine in particular of spinal cord. CT scanning is indispensible for bony details. Thus CT and MRI are complem...

journal_title：Klinische Padiatrie

authors： Hoeffel C,Gaucher H,Hoeffel JC,Galloy MA,Arnould V

更新日期：1997-03-01 00:00:00

abstract：:160 children aged 1 to 12 years with clinical diagnosis of bacterial pharyngitis and/or tonsillitis were treated either with cefixime ready-to-use-suspension or penicillin V in an open, controlled and randomized multicenter study. Before treatment a rapid antigen detection test was accomplished and throat swabs were t...

journal_title：Klinische Padiatrie

authors： Adam D,Hostalek U,Tröster K

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:It has been shown that Interleukin 10 (IL-10) is able to inhibit alloreactivity in a mixed lymphocyte culture. Therefore, here IL-10 production in patients after allogeneic BMT was investigated and correlated with the incidence of acute GvHD. PATIENTS:14 patients after allogeneic BMT have been investigated....

journal_title：Klinische Padiatrie

authors： Körholz D,Hempel L,Packeisen J,Kunst D,Zintl F,Burdach S

更新日期：1996-07-01 00:00:00

abstract：:CML is a rare malignancy in childhood not yet being treated by an established protocol of the Society of Pediatric Oncology and Hematology (GPOH). Up to now only allogeneic bone marrow transplantation (BMT) offers a curative treatment option. After being enrolled into the study "CML-päd" patients with a matched siblin...

journal_title：Klinische Padiatrie

authors： Suttorp M,Lion T,Creutzig U,Klingebiel T,Gadner H

更新日期：1996-07-01 00:00:00

abstract：:The are various opinions about the optimal therapy of endemic goiter in adolescents. From 106 patients (75 girls) suffering from endemic goiter 50 patients (group A) were treated with 300 micrograms iodine per day and 56 patients (group B) with 100 micrograms iodine plus 100 micrograms levothyroxine per day. Before th...

journal_title：Klinische Padiatrie

authors： Rönnefarth G,Kauf E,Deschner F,Forberger M

更新日期：1996-05-01 00:00:00

abstract：UNLABELLED:In the prophylaxis of stress ulcers with antacids in young infants there are no recommendations of dosages that consider the physiologic maturation of gastric acid secretion. During the first six month of life the amount of gastric acid secretion in relation to body weight and body surface area increases exp...

journal_title：Klinische Padiatrie

authors： Kentrup H,Skopnik H,Wolter L,Engelhart W,Nauert C,Heimann G

更新日期：1996-01-01 00:00:00

abstract：:Report of a case of the fetal face syndrome associated with severe oligophrenia and septum pellucidum cyste in a male patient aged 30 years. The case demonstrates the good prognosis of the hypogenitalism resp. small genitalia; the correct diagnosis in this syndrome can the patients save a plastic of the penis. ...

journal_title：Klinische Padiatrie

authors： Fehlow P,Walther F,Pfeifer T,Schuchard UM

更新日期：1995-11-01 00:00:00

abstract：:We describe two patients with neuraligic amyotrophia of the shoulder: a 15 year old boy and a girl which was 6 years old at the time of primary manifestation. Mostly adolescent patients are concerned. Beginning is acute, the etiology unclear. The patients initially feel intensive pain in one shoulder, which typically ...

journal_title：Klinische Padiatrie

authors： Weglage J,Kurlemann G

更新日期：1995-09-01 00:00:00

abstract：:An increasing number of children suffering from cancer has been treated successfully during the last 25 years using therapy protocols of the Gesellschaft für Pädiatrische Onkologie und Hämatologie. The patients had to undergo an interdisciplinary treatment modality and a mostly intensive chemotherapy. Late effects cou...

journal_title：Klinische Padiatrie

authors： Beck JD,Winkler K,Niethammer D,Brandis M,Hertzberg H,von der Hardt K,Greil J,Uberall MA,Rossi R,Lamprecht-Dinnesen A

更新日期：1995-07-01 00:00:00

abstract：:We have performed in situ hybridization (ISH) studies predominantly on paraffin sections and on isolated nuclei of 22 pediatric germ cell tumors (GCTs) from 18 patients including 4 recurrences from three patients. In addition, we performed conventional cytogenetic analyses in three tumor samples. Because reports on cy...

journal_title：Klinische Padiatrie

authors： Stock C,Ambros IM,Strehl S,Zoubek A,Fink FM,Gadner H,Ambros PF

更新日期：1995-07-01 00:00:00

abstract：:Review of a rare multisystem disorder with the main symptoms achalasia of the esophagus, alacrimia and glucocorticoid deficiency as well as multiple other symptoms especially of the nervous system. Report of one case diagnosed in the age of 11.5 years with a case history of about 7 years. Description of the danger to ...

journal_title：Klinische Padiatrie

authors： Hübschmann K

更新日期：1995-05-01 00:00:00

abstract：:Carcinomas of the plexus choroideus (PCC) represent the rare malignant variety of plexus choroideus papillomas and take a particularly unfavourable course. Tumors of the plexus choroideus account for about 2-4% of all primary brain tumors in children and 0.5% of those in adults. The PCC is more frequent in children th...

journal_title：Klinische Padiatrie

authors： Peschgens T,Stollbrink-Peschgens C,Mertens R,Völker A,Thron A,Heimann G

更新日期：1995-03-01 00:00:00